For example, last week, a 27 year old gentleman was admitted to the ward with seizures. He was too altered to give us any history, but his brother told us that he had seized three times that morning and was supposed to be taking anti-TB and anti-HIV meds (but wasn't that compliant). His CD4 count was 22. On physical exam, he was unarousable but breathing on his own with a decent pulse. Temperature was 39, neck was as stiff as a board, pupils were reactive and he extremities were completely flaccid. The possiblities here were several: bacterial meningitis, toxoplasmosis, TB meningitis or cryptococcal meningitis. History and physical could not truly differentiate these and there were no reagents in the lab to perform any blood or CSF analyses. There was no way to image the head or spinal column. What to do? I was at a loss. The physician here, however, had been through this so many times before... the answer: treat them all to the best of our ability and hope that something works. So, we put him on anti-TB meds with steroids, high dose medication for the possibility of toxo and some IV antibiotics for the possible bacterial meningitis. The pharmacy had run out of medicine to treat cryptococcal meningitis, so we couldn't bother with that. As of Friday, the patient had stopped seizing and no longer ran a fever, but wasn't waking up very much. We'll see how he is tomorrow....
The conditions under which physicians practice are extremely challenging. The wards here (pictured above) consist of concrete rectangular rooms with about 25 beds. There are often two patients per bed, each with his or her own communicable disease. The dirty walls, overpowering smells and abundance of flies and mosquitos is also disconcerting. Lab reagents and imaging studies aren't available currently (except for HIV test, CD4 count, hemoglobin, malaria smear and a chest x-ray) and sometimes the pharmacy doesn't have the appropriate medicine. These conditions make me worry that we are encouraging disease propagation rather then healing. Thankfully, many patients do improve, thanks to the ve
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